The field of organosilicon chemistry has undergone explosive growth in the past thirty years, organosilicon compounds have many applications in organic chemistry, most notably as:

• Derivatization reagents
• Blocking / Protective agents
• Intermediates in organic synthesis
• Reducing agents.

Silylating Agents

Silylating agents are reagents that are used to replace the active hydrogen of a chemical species with a silyl group (-Si RR’R”). In general, the replacement of active hydrogens significantly decreases the reactivity of a functional group and dramatically reduces polar interactions such as hydrogen bonding. These replacements can:
(1) Protect a reactive functional group during one or more chemical reactions
(2) Improve the selectivity of a chemical reaction
(3) Improve stability during distillation
(4) Improve solubility in polar and/or non-polar solvents
(5) Increase volatility by reducing or eliminating hydrogen-bonding

Reducing Agents

Hydrosilanes and hydrosiloxanes such as triethylsilanes, triisopropylsilane and 1,1,3,3-tetramethyldisiloxane are highly selective reducing agents for the reduction of carbon-carbon and carbon-heteroatom multiple bonds, as well as carbon-hydroxy and carbon-halogen single bonds.

Blocking / Protective Agents

Organosilyl Bloking Agents (Protective Agents) are widely used in organic synthesis especially in syntheses of drugs for most of them can be get easily , have a steady property , easy to use and can be get rid off in very mild conditions.

And in most of these cases, Silane Blocking Agent can protect/ deprotect functional groups selectively. It is has become a novel method for improving the process and enhancing the quality of the products in syntheses of drugs. Silane Blocking Agents (Protective Agents) are widely used in the syntheses including semi-synthesis and total synthesis of prostaglandins, 7-ADCA which is a intermediate of cephalosporin, Taxol which is a new anticance drug and Acylovir-a novel antivius drug.

• Trimethylsilyl Blocking Agents
• Trialkylsilyl Blocking Agents
• Phenyl-Containing Blocking Agents
• Specialty Silicon-Based Blocking Agents
• Bridging Silicon-Based Blocking Agents